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Any Other Causes For PKD Besides Heredity

2013-05-11 11:37

PKD (polycystic kidney disease) is a hereditary renal disorder and it can be divided into 2 types---ADPKD and ARPKD according to the the hereditary modes.

If one of the parents has ADPKD(autosomal dominant PKD), the child has 50% incidence to inherit the disease; if one of the parent has ARPKD(autosomal recessive PKD), the child will not develop the disease but the child will inherit one abnormal gene.

Though PKD is commonly considered to be inherited from the parents, there are about 40% PKD patients have no family history of the disease, that is to say, the patient is the only person in his family to have the disease. In such case, it can be caused by gene mutation and there are many factors that can cause gene mutation. For example, PKD can be caused by gene mutation during the process of embryo formation. Though such condition is rare, it does exist in clinic.

The good news is that PKD caused by gene mutation can be prevented in advance, therefore it is very necessary and important for us to know what are the high risk elements that can cause gene mutation and lead to PKD.

A variety of toxins can cause gene mutation or even congenital aplasia such as environmental pollutions, radiation, chemicals, pesticides and some certain drugs such as kanamycin, gentamicin, sulfa, rifampicin, indomethacin, nux vomica, etc. Therefore patients should try to stay away from these risk factors.

As for the pathogenesis of PKD, there is a relatively new theory called two-hit theory which holds that the onset of the disease is the result of both congenital abnormal genes and acquired factors such as infections, toxins, etc. Various infections can cause abnormal changes in the body and create a favorable internal environment to activate the cyst internal factors and promote the cyst growth. Therefore more importance should be paid and early and effective treatment should be sought to prevent more serious harms and injuries to the body.

Tag: PKD Overview

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